Cylc1^em1Hsc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cylc1^em1Hsc
• Name: cylicin, basic protein of sperm head cytoskeleton 1; endonuclease-mediated mutation 1, Hubert Schorle
• MGI ID: MGI:7341368
• Gene: Cylc1 Location: ChrX:110154024-110169624 bp, + strand Genetic Position: ChrX, 48.2 cM, cytoband D
• Alliance: Cylc1^em1Hsc page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting exon 5 generated a 1,585 kb deletion, accounting for 85% of the coding sequence, and resulted in a frameshift. (J:343074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cylc1 Mutation: 4 strains or lines available

References

• Original: J:343074 Schneider S, et al., Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human. Elife. 2023 Nov 28;12
• All: 1 reference(s)