Pck2^em1Mjme
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pck2^em1Mjme
• Name: phosphoenolpyruvate carboxykinase 2 (mitochondrial); endonuclease-mediated mutation 1, Matthew J Merrins
• MGI ID: MGI:7336345
• Synonyms: Pck2^fl
• Gene: Pck2 Location: Chr14:55777721-55787477 bp, + strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Pck2^em1Mjme page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exon 5 was flanked by loxP sites via CRISPR/Cas9 technology. (J:328491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pck2 Mutation: 33 strains or lines available

References

• Original: J:328491 Foster HR, et al., beta-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel. Elife. 2022 Aug 23;11:e79422
• All: 1 reference(s)