Hdc^em1Huhu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hdc^em1Huhu
• Name: histidine decarboxylase; endonuclease-mediated mutation 1, Hua Huang
• MGI ID: MGI:7330187
• Synonyms: Hdc^em1Huhua, Hdc^GC
• Gene: Hdc Location: Chr2:126435587-126461219 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband E5-G
• Alliance: Hdc^em1Huhu page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to delete sequences incorporating the noncoding GC box sequence (GGGCGG). The GC box sequences possess enhancer activity. mRNA expression is reduced in mast cells, basophils, brain cells, and stomach cells. (J:341581)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hdc Mutation: 51 strains or lines available

References

• Original: J:341581 Li Y, et al., The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis. J Allergy Clin Immunol. 2023 Feb 18
• All: 1 reference(s)