Arhgap11a^{em2(ARHGAP11B)Wbh}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgap11a^{em2(ARHGAP11B)Wbh}
• Name: Rho GTPase activating protein 11A; endonuclease-mediated mutation 2, Wieland B Huttner
• MGI ID: MGI:7328429
• Synonyms: 11B
• Gene: Arhgap11a Location: Chr2:113661837-113679006 bp, - strand Genetic Position: Chr2, 57.47 cM
• Alliance: Arhgap11a^{em2(ARHGAP11B)Wbh} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Arhgap11a^{em2(ARHGAP11B)Wbh} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  human	ARHGAP11B (89839)	The last 55 nucleotides of exon 5 are replaced with 141 nucleotides of the human ARHGAP11B.

• Mutation details: CRISPR/Cas9 technology replaced the last 55 nucleotides of the mouse Arhgap11a exon 5 starting at the position where in human ARHGAP11B, the C to G point mutation generates a new splice-donor site, with 141 nucleotides encoding the human ARHGAP11B-specific 47 amino acid sequence followed by three further nucleotides (TAG) to generate a translational stop codon. (J:308527)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap11a Mutation: 41 strains or lines available

References

• Original: J:308527 Xing L, et al., Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. EMBO J. 2021 Jul 1;40(13):e107093
• All: 2 reference(s)