Dcst1^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dcst1^em2Osb
• Name: DC-STAMP domain containing 1; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7328388
• Synonyms: Dcst1^d1
• Gene: Dcst1 Location: Chr3:89257526-89272560 bp, - strand Genetic Position: Chr3, 39.08 cM, cytoband F2
• Alliance: Dcst1^em2Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targetign deleted a single base pair resulting in missense mutations and premature termination after codon 75. (J:324113)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Dcst1 Mutation: 38 strains or lines available

References

• Original: J:324113 Noda T, et al., Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Commun Biol. 2022 Apr 7;5(1):332
• All: 1 reference(s)