Per2^em1Cmsu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Per2^em1Cmsu
• Name: period circadian clock 2; endonuclease-mediated mutation 1, Cam-Su Genomic Resource Center
• MGI ID: MGI:7325473
• Synonyms: Per2^m, PER2^V721G/L722G
• Gene: Per2 Location: Chr1:91343699-91387028 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^em1Cmsu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a valine to glycine (V721G; GTT to GGC) and leucine to glycine (L722G; CTG to GGC) substitutions at amino acids 721 and 722, respectively, in the PCD domain. These mutations correspond to the human V729G/L730G mutation that abolishes the PER2-CK1 association. (J:326603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 72 strains or lines available

References

• Original: J:326603 An Y, et al., Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction. Nat Commun. 2022 Jul 9;13(1):3991
• All: 1 reference(s)