Psen2^tm1.1Swyu
Targeted Allele Detail

Summary

• Symbol: Psen2^tm1.1Swyu
• Name: presenilin 2; targeted mutation 1.1, Seong-Woon Yu
• MGI ID: MGI:7316572
• Synonyms: Psen2^N141I
• Gene: Psen2 Location: Chr1:180054569-180091003 bp, - strand Genetic Position: Chr1, 84.19 cM
• Alliance: Psen2^tm1.1Swyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325409
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct modified exon 14 to include the sequence coding for the amino acid substitution of asparagine with isoleucine at position 141 (N141I). Cre-mediated recombination removed the floxed selection cassette in intron 14. (J:325409)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen2 Mutation: 32 strains or lines available

References

• Original: J:325409 Nam H, et al., Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBalpha. Nat Commun. 2022 Apr 13;13(1):1972
• All: 1 reference(s)