Lag3^em2Okat
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lag3^em2Okat
• Name: lymphocyte-activation gene 3; endonuclease-mediated mutation 2, Taku Okazaki
• MGI ID: MGI:7314843
• Gene: Lag3 Location: Chr6:124881324-124888668 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Lag3^em2Okat page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 8bp resulting in the frame shift at P111, addition of 56 irrelevant amino acids, and the generation of the premature stop codon. (J:325491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lag3 Mutation: 37 strains or lines available

References

• Original: J:325491 Maruhashi T, et al., Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Immunity. 2022 May 10;55(5):912-924.e8
• All: 1 reference(s)