Nrxn1^tm1.1Tuem
Targeted Allele Detail

Summary

• Symbol: Nrxn1^tm1.1Tuem
• Name: neurexin I; targeted mutation 1.1, Takeshi Uemura
• MGI ID: MGI:7314244
• Synonyms: Nrxn1^flox
• Gene: Nrxn1 Location: Chr17:90341059-91400499 bp, - strand Genetic Position: Chr17, 59.73 cM
• Alliance: Nrxn1^tm1.1Tuem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326377
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced upstream of an FRT-flanked neomycin resistance cassette with a 5' loxP site upstream of the last codon and an additional loxP site downstream of the coding sequence. Flp-mediated recombination removed the selection cassette. (J:326377)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrxn1 Mutation: 102 strains or lines available

References

• Original: J:326377 Uemura T, et al., Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins. Cell Rep. 2022 Apr 5;39(1):110624
• All: 2 reference(s)