Zfp36l2^tm3.1Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36l2^tm3.1Pjb
• Name: zinc finger protein 36, C3H type-like 2; targeted mutation 3.1, Perry J Blackshear
• MGI ID: MGI:7312040
• Synonyms: Zfp36l2^fl
• Gene: Zfp36l2 Location: Chr17:84491359-84495375 bp, - strand Genetic Position: Chr17, 55.02 cM, cytoband E4
• Alliance: Zfp36l2^tm3.1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270578
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 2. The neomycin selection cassette was removed via flp-mediated recombination, leaving exon 2 floxed. (J:270578)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfp36l2 Mutation: 20 strains or lines available

References

• Original: J:270578 Dumdie JN, et al., Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Dev Cell. 2018 Feb 5;44(3):392-402.e7
• All: 5 reference(s)