Mettl5^em1.2Snac
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl5^em1.2Snac
• Name: methyltransferase 5, N6-adenosine; endonuclease-mediated mutation 1.2, Sigrid Nachtergaele
• MGI ID: MGI:7310451
• Gene: Mettl5 Location: Chr2:69701542-69715959 bp, - strand Genetic Position: Chr2, 40.95 cM, cytoband C3
• Alliance: Mettl5^em1.2Snac page

Mutation origin

• Strain of Origin: (C57BL/6 x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing was used to insert loxP sites on either side of exon 2 and a FRT-flanked neomycin cassette. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 2. (J:322368)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mettl5 Mutation: 43 strains or lines available

References

• Original: J:322368 Sepich-Poore C, et al., The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation. J Biol Chem. 2022 Jan 14;298(3):101590
• All: 1 reference(s)