Igs2^{em5(CAG-Myc)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em5(CAG-Myc)Smoc}
• Name: intergenic site 2; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
• MGI ID: MGI:7290389
• Synonyms: Igs2^{em1(CAG-LSL-Myc)Smoc}, Myc^Tg
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em5(CAG-Myc)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{em5(CAG-Myc)Smoc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Myc	(MGI:97250)

• Mutation details: The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase. (J:338536)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 69 strains or lines available

References

• Original: J:338536 Wei T, et al., Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation. Cell Rep. 2023 Jul 25;42(7):112704
• All: 4 reference(s)