Tsc22d4^tm1.1Sszg
Targeted Allele Detail

Summary

• Symbol: Tsc22d4^tm1.1Sszg
• Name: Tsc22 domain family, member 4; targeted mutation 1.1, Stephan Herzig
• MGI ID: MGI:7286489
• Gene: Tsc22d4 Location: Chr5:137744274-137758011 bp, + strand Genetic Position: Chr5, 76.64 cM, cytoband G1
• Alliance: Tsc22d4^tm1.1Sszg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325407
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 1 an F3-flanked puromycin resistance cassette with a 5 prime loxP site and downstream, of exon 2 an FRT-flanked neomycin resistance cassette with a 3 prime loxP site. Flp-mediated removed the selection cassettes and left exons 1 and 2 floxed. (J:325407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tsc22d4 Mutation: 33 strains or lines available

References

• Original: J:325407 Wolff G, et al., Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function. Mol Metab. 2022 Apr 1;60:101487
• All: 2 reference(s)