Pdk3^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Pdk3^tm1Tigm
• Name: pyruvate dehydrogenase kinase, isoenzyme 3; targeted mutation 1, Texas Institute for Genomic Medicine
• MGI ID: MGI:7280948
• Gene: Pdk3 Location: ChrX:92808213-92875807 bp, - strand Genetic Position: ChrX, 41.34 cM
• Alliance: Pdk3^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 7, 8, and 9 were replaced with a LacZ-Neo cassette. (J:274759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdk3 Mutation: 7 strains or lines available

References

• Original: J:274759 Klyuyeva A, et al., Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex. J Biol Chem. 2019 Jan 18;294(3):838-851
• All: 1 reference(s)