Samd3^{tm1.1(HBEGF)Wfkr}
Targeted Allele Detail

Summary

• Symbol: Samd3^{tm1.1(HBEGF)Wfkr}
• Name: sterile alpha motif domain containing 3; targeted mutation 1.1, Wolfgang Kastenmeuller
• MGI ID: MGI:7260138
• Synonyms: Samd3^{myrtdT-DTR2WK}, Samd3^TD
• Gene: Samd3 Location: Chr10:26105605-26148070 bp, + strand Genetic Position: Chr10, 13.57 cM
• Alliance: Samd3^{tm1.1(HBEGF)Wfkr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322359
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Samd3^{tm1.1(HBEGF)Wfkr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The targeting construct introduced upstream of exon 2 a loxP site and downstream of exon 2 an inverted FRT-flanked tdTomato reporter gene and human diphtheria toxin receptor (HBEGF) with a single loxP site. Cre-mediated converted the reporter into the correct orientation. (J:322359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Samd3 Mutation: 31 strains or lines available

References

• Original: J:322359 Peters AE, et al., A multifunctional mouse model to study the role of Samd3. Eur J Immunol. 2022 Feb;52(2):328-337
• All: 1 reference(s)