Ctla4^tm2.1Shr
Targeted Allele Detail

Summary

• Symbol: Ctla4^tm2.1Shr
• Name: cytotoxic T-lymphocyte-associated protein 4; targeted mutation 2.1, Arlene H Sharpe
• MGI ID: MGI:7258397
• Synonyms: Ctla4^F
• Gene: Ctla4 Location: Chr1:60948184-60954991 bp, + strand Genetic Position: Chr1, 30.58 cM, cytoband C
• Alliance: Ctla4^tm2.1Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257993
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a floxed neomycin resistance cassette upstream of exon 2 and an additional loxP site downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:266026)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctla4 Mutation: 31 strains or lines available

References

• Original: J:257993 Sage PT, et al., The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 2014 Dec 18;41(6):1026-39
• All: 5 reference(s)