Gadd45b^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gadd45b^em1Gpt
• Name: growth arrest and DNA-damage-inducible 45 beta; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:7257805
• Synonyms: Gadd45b^em1Cflox, Gadd45beta F
• Gene: Gadd45b Location: Chr10:80765925-80768038 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gadd45b^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/Cas9 technology was used to flank exons 1-4 with loxP sites. (J:322177)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gadd45b Mutation: 13 strains or lines available

References

• Original: J:322177 Wu L, et al., Hepatic Gadd45beta promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1alpha. J Exp Med. 2021 May 3;218(5)
• All: 1 reference(s)