Gria2^tm3.1Rlh
Targeted Allele Detail

Summary

• Symbol: Gria2^tm3.1Rlh
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 3.1, Richard Huganir
• MGI ID: MGI:6864289
• Synonyms: GluA2 Y876F
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm3.1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285753
• Parent Cell Line: MCI (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct is designed to insert an adenosine to thymidine point mutation, resulting in a tyrosine to phenylalanine substitution at position 876 (Y876F). A loxP-flanked neomycin (neo) resistance cassette, in opposite orientation to the gene, is placed upstream of the mutated exon. Germ line, cre mediated recombination removed the neo cassette. (J:285753)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 78 strains or lines available

References

• Original: J:285753 Yong AJH, et al., Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4948-4958
• All: 1 reference(s)