Fcer1g^{tm1d(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Fcer1g^{tm1d(KOMP)Wtsi}
• Name: Fc receptor, IgE, high affinity I, gamma polypeptide; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:6856616
• Gene: Fcer1g Location: Chr1:171057141-171061918 bp, - strand Genetic Position: Chr1, 79.23 cM
• Alliance: Fcer1g^{tm1d(KOMP)Wtsi} page
• IMPC: Fcer1g gene page

Mutation origin

• Mutant Cell Line: EPD0852_5_A05
• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 171058409 of Chromosome 1 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 171059392. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression resulted in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcer1g Mutation: 31 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)