Abcb10^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Abcb10^tm1.1Geno
• Name: ATP-binding cassette, sub-family B member 10; targeted mutation 1.1, Genoway
• MGI ID: MGI:6849952
• Synonyms: Abcb10^flox
• Gene: Abcb10 Location: Chr8:124679198-124709861 bp, - strand Genetic Position: Chr8, 72.31 cM
• Alliance: Abcb10^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317104
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 2 and 3 and inserted an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:317104)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcb10 Mutation: 39 strains or lines available

References

• Original: J:317104 Shum M, et al., ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity. Sci Transl Med. 2021 May 19;13(594)
• All: 3 reference(s)