Dppa2^tm1.2Reik
Targeted Allele Detail

Summary

• Symbol: Dppa2^tm1.2Reik
• Name: developmental pluripotency associated 2; targeted mutation 1.2, Wolf Reik
• MGI ID: MGI:6845043
• Gene: Dppa2 Location: Chr16:48130637-48139876 bp, + strand Genetic Position: Chr16, 30.75 cM
• Alliance: Dppa2^tm1.2Reik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316936
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted upstream of exon 2 a loxP site and downstream of exon 2 a self-excising neomycin resistance cassette with a 3 prime loxP site. The final allele lacks the selection cassette. Cre-mediated recombination removed exon 2. (J:316936)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dppa2 Mutation: 27 strains or lines available

References

• Original: J:316936 Kubinyecz O, et al., Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival. Development. 2021 Dec 15;148(24):dev200191
• All: 1 reference(s)