Rr130^em1Linhe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr130^em1Linhe
• Name: regulatory region 130; endonuclease-mediated mutation 1, Lin He
• MGI ID: MGI:6841008
• Synonyms: Cdk2ap1^{deltaN(MT2B2)}
• Gene: Rr130 Location: Chr5:124501013-124501116 bp Genetic Position: Chr5, Syntenic
• Alliance: Rr130^em1Linhe page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s), Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: The targeting construct deleted a 1.2kb region surrounding the 0.7 kb MT2B2 locus (8.2 kb upstream of Cdk2ap1). The allele fails to produce the N-terminally truncated isoform of Cdk2ap1. (J:312811)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr130 Mutation: 0 strains or lines available

References

• Original: J:312811 Modzelewski AJ, et al., A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Cell. 2021 Oct 28;184(22):5541-5558.e22
• All: 1 reference(s)