Plin5^tm1.1Peb
Targeted Allele Detail

Summary

• Symbol: Plin5^tm1.1Peb
• Name: perilipin 5; targeted mutation 1.1, Perry E Bickel
• MGI ID: MGI:6832797
• Synonyms: Plin5^loxP
• Gene: Plin5 Location: Chr17:56418601-56424596 bp, - strand Genetic Position: Chr17, 29.16 cM
• Alliance: Plin5^tm1.1Peb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315837
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3-8 were flanked by loxP sites. An FRT-flanked PGK-neomycin cassette was inserted downstream of the floxed exon 8 and was removed via flp-mediated recombination. (J:315837)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plin5 Mutation: 24 strains or lines available

References

• Original: J:315837 Gallardo-Montejano VI, et al., Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance. Nat Commun. 2021 Jun 3;12(1):3320
• All: 1 reference(s)