Nlrc5^tm1Rfw
Targeted Allele Detail

Summary

• Symbol: Nlrc5^tm1Rfw
• Name: NLR family, CARD domain containing 5; targeted mutation 1, Rong-Fu Wang
• MGI ID: MGI:6831632
• Gene: Nlrc5 Location: Chr8:95160984-95253900 bp, + strand Genetic Position: Chr8, 46.55 cM
• Alliance: Nlrc5^tm1Rfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315816
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 8 was replaced with a neomycin cassette via homologous recombination, leading to premature termination. (J:315816)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc5 Mutation: 68 strains or lines available

References

• Original: J:315816 Tong Y, et al., Enhanced TLR-induced NF-kappaB signaling and type I interferon responses in NLRC5 deficient mice. Cell Res. 2012 May;22(5):822-35
• All: 1 reference(s)