Zeb1^tm1.1Dpbl
Targeted Allele Detail

Summary

• Symbol: Zeb1^tm1.1Dpbl
• Name: zinc finger E-box binding homeobox 1; targeted mutation 1.1, David P Bartel
• MGI ID: MGI:6829619
• Synonyms: Zeb1²⁰⁰, Zeb1^tm1.1Stf
• Gene: Zeb1 Location: Chr18:5591860-5775467 bp, + strand Genetic Position: Chr18, 4.42 cM
• Alliance: Zeb1^tm1.1Dpbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267194
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting cassette replaced exon 8 with one in which all Mir200 target sites are mutated. A loxP-CMV-puromycin-loxP cassette was placed in intron 7. This allele was derived from clone 6B6 ES cells after homologous recombination. Cre-mediated recombination removed the floxed puromycin resistance cassette. (J:101977, J:267194)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zeb1 Mutation: 67 strains or lines available

References

• Original: J:267194 Title AC, et al., Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion. Nat Commun. 2018 Nov 7;9(1):4671
• All: 4 reference(s)