Lcp1^em1Shcm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lcp1^em1Shcm
• Name: lymphocyte cytosolic protein 1; endonuclease-mediated mutation 1, Sharon Celeste Morley
• MGI ID: MGI:6827451
• Synonyms: S5A
• Gene: Lcp1 Location: Chr14:75368570-75468282 bp, + strand Genetic Position: Chr14, 39.63 cM
• Alliance: Lcp1^em1Shcm page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a serine to alanine change at residue 5 (S5A). Immunoblot analysis confirmed no detectable phosphorylation of serine at residue 5. (J:307960)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcp1 Mutation: 43 strains or lines available

References

• Original: J:307960 Anaya EP, et al., Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin Is Essential for Effective Splenic Clearance of Pneumococcus. J Immunol. 2021 May 1;206(9):2135-2145
• All: 3 reference(s)