Rr27^tm1.1Ricc
Targeted Allele Detail

Summary

• Symbol: Rr27^tm1.1Ricc
• Name: regulatory region 27; targeted mutation 1.1, Andrea Riccio
• MGI ID: MGI:6780029
• Synonyms: hIC1^delta1.8
• Gene: Rr27 Location: Chr7:142133885-142136283 bp Genetic Position: Chr7, Syntenic
• Alliance: Rr27^tm1.1Ricc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308687
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the endogenous imprinting control region (ICR) with a mutant corresponding human sequence that deletes a 1.8 kb region found in a familial case of Beckwith-Wiedemann syndrome. Cre-mediated recombination removed a floxed neomycin resistance cassette inserted downstream of the human sequence. (J:308687)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr27 Mutation: 7 strains or lines available

References

• Original: J:308687 Freschi A, et al., The number of the CTCF binding sites of the H19/IGF2:IG-DMR correlates with DNA methylation and expression imprinting in a humanized mouse model. Hum Mol Genet. 2021 Jul 28;30(16):1509-1520
• All: 1 reference(s)