Kpna6^em1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Kpna6^em1Btlr
• Name: karyopherin subunit alpha 6; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6761438
• Synonyms: Kpna6^{p.Lys6LysfsTer8}
• Gene: Kpna6 Location: Chr4:129537773-129566560 bp, - strand Genetic Position: Chr4, 63.28 cM, cytoband D2.3
• Alliance: Kpna6^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Not Specified
• Mutation details: CRISPR-targeting produced a deletion mutation (chr4:g.129555212_129555213delTC) resulting in a frameshift and premature stop codon (p.Lys6Glyfs*9). (J:309727)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpna6 Mutation: 42 strains or lines available

References

• Original: J:309727 Rios JJ, et al., Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. J Bone Miner Res. 2021 Aug;36(8):1548-1565
• All: 1 reference(s)