Plin5^tm1.1Macl
Targeted Allele Detail

Summary

• Symbol: Plin5^tm1.1Macl
• Name: perilipin 5; targeted mutation 1.1, Malin C Levin
• MGI ID: MGI:6759004
• Synonyms: Plin5^-
• Gene: Plin5 Location: Chr17:56418601-56424596 bp, - strand Genetic Position: Chr17, 29.16 cM
• Alliance: Plin5^tm1.1Macl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301535
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 were replaced with a hygromycin resistance gene flanked by FRT5 sites via homologous recombination. Flp-mediated recombination removed the hygromycin selection cassette. (J:286482, J:301535)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plin5 Mutation: 25 strains or lines available

References

• Original: J:301535 Li Y, et al., Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec 26;1866(4):158873
• All: 2 reference(s)