Ppm1d^em1Lima
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppm1d^em1Lima
• Name: protein phosphatase 1D magnesium-dependent, delta isoform; endonuclease-mediated mutation 1, Libor Macurek
• MGI ID: MGI:6758554
• Synonyms: Ppm1d^T
• Gene: Ppm1d Location: Chr11:85202080-85237897 bp, + strand Genetic Position: Chr11, 51.34 cM
• Alliance: Ppm1d^em1Lima page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 6 was targeted with two TALENs, resulting in a 16 bp deletion (c.1324_1339del16) leading to a frameshift and premature top codon (p.F442Lfs*3). (J:285557)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppm1d Mutation: 33 strains or lines available

References

• Original: J:285557 Burocziova M, et al., Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell Death Dis. 2019 Oct 28;10(11):818
• All: 3 reference(s)