Pappa2^tm1.2Jkcs
Targeted Allele Detail

Summary

• Symbol: Pappa2^tm1.2Jkcs
• Name: pappalysin 2; targeted mutation 1.2, Julian K Christians
• MGI ID: MGI:6758253
• Synonyms: PAPP-A2 floxed
• Gene: Pappa2 Location: Chr1:158539297-158788019 bp, - strand Genetic Position: Chr1, 68.49 cM
• Alliance: Pappa2^tm1.2Jkcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct contains from 5' to 3' a loxP site upstream of exon 2 and an FRT-flanked neomycin cassette followed by a second loxP site downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:199327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pappa2 Mutation: 88 strains or lines available

References

• Original: J:199327 Christians JK, et al., Pregnancy associated plasma protein A2 (PAPP-A2) affects bone size and shape and contributes to natural variation in postnatal growth in mice. PLoS One. 2013;8(2):e56260
• All: 2 reference(s)