Neat1^em1Shna
Endonuclease-mediated Allele Detail

Summary

• Symbol: Neat1^em1Shna
• Name: nuclear paraspeckle assembly transcript 1 (non-protein coding); endonuclease-mediated mutation 1, Shinichi Nakagawa
• MGI ID: MGI:6729929
• Synonyms: Neat^deltaPAS
• Gene: Neat1 Location: Chr19:5874736-5895508 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Neat1^em1Shna page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR targeting removed the sequence encoding the upstream polyadenylation (poly-A) signal (PAS). The allele produces only isoform 1 and not isoform 2. (J:292009)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neat1 Mutation: 224 strains or lines available

References

• Original: J:292009 Isobe M, et al., Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice. RNA. 2020 Mar;26(3):251-264
• All: 2 reference(s)