Adar^em#Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adar^em#Osb
• Name: adenosine deaminase, RNA-specific; endonuclease-mediated mutation, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6728507
• Synonyms: Adar1 p110^-
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^em#Osb page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s), Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted the constitutive promoter, exon 1B, and a possible alternative exon 1C required for the transcription of the p110 isoform. Expression of isoform p150 is not altered. Two lines were generated with almost identical mutations. The two lines (Adar^em3Osb and Adar^em4Osb) were combined (indicated by the pound symbol #). (J:306164)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 83 strains or lines available

References

• Original: J:306164 Kim JI, et al., RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain. PLoS Genet. 2021 May;17(5):e1009516
• All: 2 reference(s)