Adarem4Osb
Endonuclease-mediated Allele Detail
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| Symbol: |
Adarem4Osb |
| Name: |
adenosine deaminase, RNA-specific; endonuclease-mediated mutation 3, Research Institute for Microbial Diseases, Osaka University |
| MGI ID: |
MGI:6728522 |
| Synonyms: |
Adar1 p110- line 17 |
| Gene: |
Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
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| Alliance: |
Adarem4Osb page
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| Strain of Origin: |
Not Applicable
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| Allele Type: |
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Endonuclease-mediated (Modified isoform(s), Modified regulatory region) |
| Mutation: |
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Intragenic deletion
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Mutation details: CRISPR-targeting deleted the constitutive promoter, exon 1B, and a possible alternative exon 1C required for the transcription of the p110 isoform (chr3: 89714040-89715631; build 38). Expression of isoform p150 is not altered.
(J:306164)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Adar Mutation: |
83 strains or lines available
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| Original: |
J:306164 Kim JI, et al., RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain. PLoS Genet. 2021 May;17(5):e1009516 |
| All: |
1 reference(s) |
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Analysis Tools
