Klb^tm1(cre)Mglm
Targeted Allele Detail

Summary

• Symbol: Klb^tm1(cre)Mglm
• Name: klotho beta; targeted mutation 1, Matthew Gillum
• MGI ID: MGI:6727118
• Synonyms: Klb-CRE
• Gene: Klb Location: Chr5:65505657-65541350 bp, + strand Genetic Position: Chr5, 33.64 cM
• Alliance: Klb^tm1(cre)Mglm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Klb^tm1(cre)Mglm expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Klb (MGI:1932466)

• Mutation details: The allele was generated by inserting, in frame with the b-klotho (gene symbol: Klb) ATG in exon 1, a construct containing the CRE recombinase and the tdTomato reporter coding sequence separated by an IRES sequence via homologous recombination. (J:296603)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Klb (mouse) Summary of all recombinase alleles driven by Klb. Comparative matrix view of recombinase activities Alliance mouse Klb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klb Mutation: 58 strains or lines available

References

• Original: J:296603 Jensen-Cody SO, et al., FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. Cell Metab. 2020 Aug 4;32(2):273-286.e6
• All: 3 reference(s)