Mir378b^em#Yoo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir378b^em#Yoo
• Name: microRNA 378b; endonuclease-mediated mutation, Yusuf O Omosun
• MGI ID: MGI:6724587
• Synonyms: miR-378b^-
• Gene: Mir378b Location: Chr11:88243599-88243690 bp, + strand Genetic Position: Chr11, 52.4 cM
• Alliance: Mir378b^em#Yoo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using gRNA 2 and 3 (sequence not provided) deleted most of this microRNA and using gRNA 1 and 3 deleted the entire microRNA. The pound (#) symbol is used for the pool of these two alleles. (J:307588)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir378b Mutation: 0 strains or lines available

References

• Original: J:307588 Lundy SR, et al., MiR-378b Modulates Chlamydia-Induced Upper Genital Tract Pathology. Pathogens. 2021 May 7;10(5)
• All: 1 reference(s)