Panx1^em1Icg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Panx1^em1Icg
• Name: pannexin 1; endonuclease-mediated mutation 1, Institute of Cytology and Genetics
• MGI ID: MGI:6724373
• Synonyms: Panx1^em1Koral/Icg
• Gene: Panx1 Location: Chr9:14917081-14956774 bp, - strand Genetic Position: Chr9, 4.52 cM
• Alliance: Panx1^em1Icg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 and 4 were targeted for deletion with two sgRNA (targeting GGGACGCTGGCTGATCATGTTGG and GCGAGTTCGTCCCTGAAATGAGG) and an ssODN (GACATGGCCTGGATCATGGACTTGCTACAGCTCAGCTACACAAGATGAAGAGAGCCAACAAGCTTCAGGGACGAACTCGCATCCCCACGTCACTGACAGACACCTGCCTGCTGCCTGTTGATT) using CRISPR/Cas9 technology, resulting in the deletion of the two exons. (J:307589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Panx1 Mutation: 41 strains or lines available

References

• Original: J:307589 Battulin N, et al., Pannexin 1 Transgenic Mice: Human Diseases and Sleep-Wake Function Revision. Int J Mol Sci. 2021 May 17;22(10)
• All: 1 reference(s)