Dcaf8^em1Rbren
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dcaf8^em1Rbren
• Name: DDB1 and CUL4 associated factor 8; endonuclease-mediated mutation 1, Ruibao Ren
• MGI ID: MGI:6724058
• Synonyms: Dcaf8 KO
• Gene: Dcaf8 Location: Chr1:171975574-172023960 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Dcaf8^em1Rbren page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 gene-editing approaches, mutations to exon 6 of the Dcaf8 gene causing an insertion of a fragment of 115 base pair nucleotides, which resulted in a frameshift in its coding sequence was generated. (J:307635)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcaf8 Mutation: 125 strains or lines available

References

• Original: J:307635 Brandao R, et al., ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. FEBS Open Bio. 2021 Jun;11(6):1579-1592
• All: 2 reference(s)