Rtkn2^{em1(cre/ERT2)Jich}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rtkn2^{em1(cre/ERT2)Jich}
• Name: rhotekin 2; endonuclease-mediated mutation 1, Jichao Chen
• MGI ID: MGI:6721138
• Synonyms: Rtkn2^CreER
• Gene: Rtkn2 Location: Chr10:67815371-67894259 bp, + strand Genetic Position: Chr10, 35.06 cM
• Alliance: Rtkn2^{em1(cre/ERT2)Jich} page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Rtkn2^{em1(cre/ERT2)Jich} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rtkn2 (MGI:2158417)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a CreERT2 expression cassette under the control of Rtkn2 gene. (J:307465)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rtkn2 (mouse) Summary of all recombinase alleles driven by Rtkn2. Comparative matrix view of recombinase activities Alliance mouse Rtkn2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rtkn2 Mutation: 39 strains or lines available

References

• Original: J:307465 Little DR, et al., Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Nat Commun. 2021 May 4;12(1):2509
• All: 2 reference(s)