Slc24a4^tm1Jlyt
Spontaneous Allele Detail

Summary

• Symbol: Slc24a4^tm1Jlyt
• Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; targeted mtation 1, Johathan Lytton
• MGI ID: MGI:6719381
• Gene: Slc24a4 Location: Chr12:102094992-102233350 bp, + strand Genetic Position: Chr12, 51.42 cM
• Alliance: Slc24a4^tm1Jlyt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306585
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including exons 6 and 7 was replaced with a neo cassette via homologous recombination. (J:306585)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc24a4 Mutation: 35 strains or lines available

References

• Original: J:306585 Li XF, et al., An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety. J Biol Chem. 2014 Sep 12;289(37):25445-59
• All: 3 reference(s)