Cylc2^em1Hsc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cylc2^em1Hsc
• Name: cylicin, basic protein of sperm head cytoskeleton 2; endonuclease-mediated mutation 1, Hubert Schorle
• MGI ID: MGI:6718280
• Gene: Cylc2 Location: Chr4:51216678-51250622 bp, + strand Genetic Position: Chr4, 27.27 cM, cytoband B3
• Alliance: Cylc2^em1Hsc page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 1145 bp leading to loss of exon 4 and exon 5. (J:343074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cylc2 Mutation: 27 strains or lines available

References

• Original: J:343074 Schneider S, et al., Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human. Elife. 2023 Nov 28;12
• All: 1 reference(s)