Igs2^{em7(Gfap-icre)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em7(Gfap-icre)Gpt}
• Name: intergenic site 2; endonuclease-mediated mutation 7, GemPharmatech Co., Ltd
• MGI ID: MGI:6718252
• Synonyms: GFAP-Cre, H11^{em1Cin(GFAP-iCre)}, H11-Gfap-iCre
• Gene: Igs2 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em7(Gfap-icre)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Igs2^{em7(Gfap-icre)Gpt} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gfap (MGI:95697)

• CRISPR-targeting introduced an icre driven by the mouse Gfap promoter into Igs2 H11 docking site. (J:306747)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gfap (mouse) Summary of all recombinase alleles driven by Gfap. Alliance mouse Gfap gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 68 strains or lines available

References

• Original: J:306747 Liu W, et al., Deubiquitinase USP18 regulates reactive astrogliosis by stabilizing SOX9. Glia. 2021 Jul;69(7):1782-1798
• All: 2 reference(s)