Foxl1^{tm2(cre/ERT2)Khk}
Targeted Allele Detail

Summary

• Symbol: Foxl1^{tm2(cre/ERT2)Khk}
• Name: forkhead box L1; targeted mutation 2, Klaus H Kaestner
• MGI ID: MGI:6711487
• Synonyms: Foxl1CreERT2-2A-tdTomato, FoxL1^CreER-tdTom
• Gene: Foxl1 Location: Chr8:121854679-121857383 bp, + strand Genetic Position: Chr8, 70.34 cM
• Alliance: Foxl1^{tm2(cre/ERT2)Khk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:313017
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Foxl1^{tm2(cre/ERT2)Khk} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxl1 (MGI:1347469)

• Mutation details: The targeting vector contains a Cre recombinase/ERT2 fusion, a viral 2A oligopeptide that mediates ribosomal skipping, and a tdTomato reporter followed by neomycin resistance cassette inserted after the ATG site in exon 1. The insertion deletes 200 bp of the coding sequence rendering the allele null. (J:94077, J:313017)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxl1 (mouse) Summary of all recombinase alleles driven by Foxl1. Comparative matrix view of recombinase activities Alliance mouse Foxl1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxl1 Mutation: 10 strains or lines available

References

• Original: J:313017 Kolev HM, et al., A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes. Cell Mol Gastroenterol Hepatol. 2021;12(3):1155-1158.e4
• All: 3 reference(s)