Top1^tm1Hon
Targeted Allele Detail

Summary

• Symbol: Top1^tm1Hon
• Name: topoisomerase (DNA) I; targeted mutation 1, Tasuku Honjo
• MGI ID: MGI:6690606
• Synonyms: Top1^fl
• Gene: Top1 Location: Chr2:160487901-160564684 bp, + strand Genetic Position: Chr2, 80.96 cM, cytoband H2-3
• Alliance: Top1^tm1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303117
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• An frt-flanked neomycin selection cassette and two loxP sites were inserted to flank exon 15. (J:303117)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Top1 Mutation: 213 strains or lines available

References

• Original: J:303117 Kobayashi M, et al., Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19305-10
• All: 1 reference(s)