Rasa3^tm1Llp
Targeted Allele Detail

Summary

• Symbol: Rasa3^tm1Llp
• Name: RAS p21 protein activator 3; targeted mutation 1, Luanne Peters
• MGI ID: MGI:6508552
• Gene: Rasa3 Location: Chr8:13617218-13727590 bp, - strand Genetic Position: Chr8, 6.29 cM
• Alliance: Rasa3^tm1Llp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301035
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S3/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: Using the knockout-first promoter driven conditional ready construct from the trans-NIH Knockout Mouse Project, this conditional-ready allele has an FRT site followed by lacZ sequence and a loxP site, followed by neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site all upstream of exon 3 with a third loxP site is inserted downstream of exon 3. (J:301035)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasa3 Mutation: 62 strains or lines available

References

• Original: J:301035 Robledo RF, et al., Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant. PLoS Genet. 2020 Dec;16(12):e1008857
• All: 1 reference(s)