Glrx3^tm1.1Nihc
Targeted Allele Detail

Summary

• Symbol: Glrx3^tm1.1Nihc
• Name: glutaredoxin 3; targeted mutation 1.1, Ninghui Cheng
• MGI ID: MGI:6504905
• Synonyms: Grx3^flox
• Gene: Glrx3 Location: Chr7:137039343-137070323 bp, + strand Genetic Position: Chr7, 82.32 cM, cytoband F5
• Alliance: Glrx3^tm1.1Nihc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244214
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin cassette and reversed loxP site are introduced to intron 1 and a reversed loxP site is placed in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:244214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Glrx3 Mutation: 33 strains or lines available

References

• Original: J:244214 Pham K, et al., Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 Mar 01;312(3):E136-E149
• All: 3 reference(s)