Rr139^em1Makm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr139^em1Makm
• Name: regulatory region 139; endonuclease-mediated mutation 1, Marie Kmita
• MGI ID: MGI:6500991
• Synonyms: Hoxa11^deltaInt, Hoxa11^em1Makm
• Gene: Rr139 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr139^em1Makm page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of Hoxa11 intron 1 deleted 1168 bp containing the distal or digit enhancer that promotes expression of Hoxa11os, and consequently repression of Hoxa11, upon Hoxa13-binding. (J:239414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr139 Mutation: 0 strains or lines available

References

• Original: J:239414 Kherdjemil Y, et al., Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state. Nature. 2016 Nov 03;539(7627):89-92
• All: 1 reference(s)