Cdh23^em1Qzn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdh23^em1Qzn
• Name: cadherin related 23 (otocadherin); endonuclease-mediated mutation 1, Qing Zheng
• MGI ID: MGI:6490579
• Synonyms: Cdh23^erl2Qzn
• Gene: Cdh23 Location: Chr10:60138527-60532269 bp, - strand Genetic Position: Chr10, 30.11 cM
• Alliance: Cdh23^em1Qzn page

Mutation origin

• Strain of Origin: CBA/CaJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced a point mutation (c.208T>C) in the middle region of exon 3 (Genbank accession number: NM_023370) causing an amino acid substitution (p.S70P). (J:348046)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh23 Mutation: 275 strains or lines available

References

• Original: J:348046 Zhao T, et al., Phenotypic differences in the inner ears of CBA/CaJ and C57BL/6J mice carrying missense and single base pair deletion mutations in the Cdh23 gene. J Neurosci Res. 2021 Oct;99(10):2743-2758
• All: 1 reference(s)