Mettl5^em1Schne
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl5^em1Schne
• Name: methyltransferase 5, N6-adenosine; endonuclease-mediated mutation 1, Robert Schneider
• MGI ID: MGI:6488597
• Gene: Mettl5 Location: Chr2:69701542-69715959 bp, - strand Genetic Position: Chr2, 40.95 cM, cytoband C3
• Alliance: Mettl5^em1Schne page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination created a 23 bp deletion in exon 1 resulting in a frameshift mutation and premature stop in exon 2. (J:289086)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl5 Mutation: 40 strains or lines available

References

• Original: J:289086 Ignatova VV, et al., The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes Dev. 2020 May 1;34(9-10):715-729
• All: 2 reference(s)