Gdpd2^tm1.1Soc
Targeted Allele Detail

Summary

• Symbol: Gdpd2^tm1.1Soc
• Name: glycerophosphodiester phosphodiesterase domain containing 2; targeted mutation 1.1, Shanthini Sockanathan
• MGI ID: MGI:6487892
• Synonyms: Gde3^-
• Gene: Gdpd2 Location: ChrX:99773479-99782501 bp, + strand Genetic Position: ChrX, 43.72 cM, cytoband C2
• Alliance: Gdpd2^tm1.1Soc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291492
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 7 and a second loxP site into intron 10, creating a conditional-ready allele with exons 8-10 floxed. An FRT site flanked neomycin resistance gene cassette was also inserted. Exons 8-10 were deleted through subsequent cre-mediated recombination. In situ hybridization and Western blots confirmed the absence of transcript and peptide expression from this allele. (J:291492)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdpd2 Mutation: 8 strains or lines available

References

• Original: J:291492 Dobrowolski M, et al., GDE3 regulates oligodendrocyte precursor proliferation via release of soluble CNTFRalpha. Development. 2020 Jan 23;147(2):dev180695
• All: 2 reference(s)